The small town of Bon Temps, Louisiana boasts a wide array of colorful locals. Sookie Stackhouse is a sweet and innocent waitress who hides her powerful ability to read minds. Bill Compton is a 173 year-old vampire who's just moved back to town. Sookie's brother Jason is a ladies' man who can't seem to stay out of trouble. Tough-as-nails Tara is Sookie's loyal best friend and Sam is the owner of Merlotte's who tries to keep his feelings for Sookie...

Having grown up in Roswell with only a few close friends aware that they are really aliens, Max, Isabel and MIchael have come of age. Uncertain about their future, they are forced into action when it become apparent that the use of their alien powers to help others has caught up with them. With the Air Force and the FBI closing in, Liz has a vision and realizes that not only the aliens are in danger, but also their human friends.