The Mousekewitz family discovers the streets of America are not all paved with cheese, and living in a mouse tenement does not offer the life they hoped for. Young Tanya dreams of becoming a famous singer, and Fievel wants to become a tough lawdog like his hero Wylie Burp. Lured out west by the crafty entrepreneur Cat R. Waul, Fievel discovers the evil gentleman's true plans to turn the settlers into mouse-burgers. Enlisting the aid of his cat friend...

Jackie Draper is a shy boy who learns the value of courage from his beloved companion, Puff. Then, Puff helps a young girl deal with her parents' divorce. Lastly, Puff teaches a gifted boy to believe in his own creative abilities.